I’ve been working within the males’s well being discipline since 1969. My work expanded drastically in 1997 following the publication of my fourth guide, Male Menopause, which quickly turned a world best-seller translated into seventeen international languages. Within the guide I outlined the male “change of life” this manner:
“Male menopause (additionally referred to as andropause or manopause) begins with hormonal, physiological, and chemical adjustments that happen in all males usually between the ages of forty and fifty-five, although it might probably happen as early as thirty-five or as late as sixty-five. These adjustments have an effect on all elements of a person’s life. Male menopause is, thus, a bodily situation with psychological, interpersonal, social, and non secular dimensions.”
I went on to say,
“The aim of male menopause is to sign the top of the primary a part of a person’s life and put together him for the second half. Male menopause shouldn’t be the start of the top, as many concern, however the finish of the start. It’s the passage to essentially the most passionate, highly effective, productive, and purposeful time of a person’s life.”
I listed the next signs I had seen over time with shoppers I handled. Probably the most frequent bodily signs embrace:
- Much less endurance for bodily exercise
- Taking longer to get well from accidents and sickness
- Weight achieve
- Lack of pores and skin tone
Widespread psychological signs embrace:
- Irritability
- Anxiousness
- Despair
- Lack of goal and course in life
Widespread sexual signs embrace:
- Lack of erections
- Low libido and curiosity in intercourse
- Elevated anxiousness and concern about sexual adjustments
- Elevated fantasies about having intercourse exterior of main relationship
I mentioned the influence of hormonal adjustments for males going via this life passage.
“Lowered ranges of hormones at midlife are central to the adjustments related to male menopause. Though hormones are inclined to lower with age, every man is exclusive and particular person ranges differ broadly. In a single research, for example, the common degree of testosterone for males of their fifties was 600 ng/ mL. Nevertheless, particular person ranges ranged from 200 ng/ mLl to 1,000 ng/ mL.”
I additionally detailed the early experiences with testosterone substitute therapies (TRT) and among the considerations about its use.
“Whereas clinicians within the U.S. debated the dangers and advantages of TRT, British physicians have been already starting to make use of hormones to deal with males who confirmed signs of testosterone deficiency.”
Over time, there continues to be controversy about using TRT in treating males. However, testosterone continues to be prescribed broadly for tens of millions of males. I not too long ago wrote a couple of new firm, GameDay Males’s Well being, that has been increasing quickly with new clinics all through the nation. Says their founder, Evan Miller, PhD,
“By focusing all of our power on delivering premium testosterone substitute remedy, eradicating the stigma round erectile dysfunction companies and extra, we guarantee our shoppers’ expertise is stress-free, quick, and most significantly, delivers outcomes.”
Acesis BioMed: Revolutionizing Remedy of Low T and Different Well being Issues
I not too long ago discovered a couple of new firm, Acesis Biomed, that’s taking a special strategy to treating low testosterone in males. Acesis Biomed was based by Dr. Vassilios Papadopoulos and Dr. Costas N. Karatzas.
Dr. Papadopoulos is Dean of the College of Southern California Alfred Mann Faculty of Pharmacy & Pharmaceutical Sciences. He holds the John Stauffer Decanal Chair in Pharmaceutical Sciences and is a professor of Pharmacology and Pharmaceutical Sciences and Drugs at USC. Earlier than becoming a member of USC, Dr Papadopoulos served as Government Director and Chief Scientific Officer of the Analysis Institute of McGill College Well being Centre in Montreal, Canada.
Dr. Karatzas is Acesis’ CEO and has over 35 years of expertise in Life Sciences within the public, personal and educational sectors. He attended McGill College, the place he earned his Ph.D., in Molecular Biology. He has over fifty peer-reviewed publications and is an inventor with 18 patents. From 2009 to 2021 he was the Director of Enterprise Improvement and Contracts Workplace on the Analysis Institute of the McGill College Well being Centre, Montreal, Canada.
I not too long ago had a possibility to speak with Drs. Papadopoulos and Karatzas about their firm and their new strategy for serving to males with low T. They instructed me,
“Tens of millions of males endure from low testosterone (T), resulting in decreased high quality of life. Acesis Biomed is pioneering a first-in-class, patented, oral remedy that restores the physique’s pure T manufacturing — with out artificial hormones.”
From my expertise working with mid-life males and their households for greater than fifty years, I imagine it is a monumental breakthrough in what might be supplied to males. Up till now, males who have been experiencing signs of low testosterone have been restricted to taking Testosterone Substitute Remedy (TRT). Now, for the primary time, Acesis Biomed, is providing a remedy strategy that helps males restore their testosterone ranges via a probably safer and extra pure strategy by inducing the testes to supply testosterone.
“Our imaginative and prescient is to unlock the physique’s capacity to revive testosterone, slightly than utilizing exterior steroids, setting a brand new strategy for males’s wellbeing,” they instructed me.
They proceed by stating:
“What if a tablet may assist tens of millions of males really feel like themselves once more — with out needles, patches, gels or artificial hormones? At Acesis, we’re on a mission to rework the best way low-T or deficiency is handled.“
Dr. Karatzas acknowledged that,
“Our distinctive resolution is rooted within the science, developed by Dr. Papadopoulos. His analysis has led to a greater understanding of the pathways resulting in steroid hormone synthesis, the pharmacology of steroid formation within the periphery and mind, and the identification of latest molecules concentrating on key parts in illnesses the place steroids play a figuring out function.”
They instructed me they need to ensure that when this new remedy is obtainable, it’s protected and has undergone the required scientific trials and regulatory scrutiny.
“Our present objective is to finish our preclinical program and transition to First-in-Man scientific trial in males with low testosterone, also referred to as male hypogonadism.”
As a pacesetter within the discipline of Gender-Particular Drugs and Males’s Well being I’m excited to proceed studying extra concerning the ground-breaking work that Drs. Papadopoulos and Karatzas are doing.
The sphere of Gender-Particular Drugs is comparatively new. My colleague, Marianne J. Legato, MD based the Basis for Gender-Particular Drugs in 1999. In her guide, Eve’s Rib: The New Science of Gender-Particular Drugs and How It Can Save Your Life, she says,
“Till now, we’ve acted as if women and men are basically similar apart from the variations of their reproductive perform. The truth is, info we’ve been gathering over the previous ten years tells us that that is something however true, and in every single place we glance, the 2 sexes are startingly and unexpectedly totally different not solely of their regular perform however in the best way they expertise sickness.”
Dr. Legato has instructed me on quite a few events that there’s a nice want for brand new approaches to serving to males. In her guide, Why Males Die First: Lengthen Your Lifespan, she says,
“Regardless of the numerous alternatives and benefits most societies afford males, they continue to be shockingly weak on many ranges. Researchers have largely ignored the phenomenon, with tragic penalties. Merely put, we by no means turned a gender-specific lens on males. We now have not thought sufficient — if in any respect — about why they’re uniquely susceptible to incapacity and untimely demise.”
It’s time that males’s well being acquired the popularity it deserves. I’ll preserve my readers posted on these improvements and stay up for listening to extra from Dr. Vassilios Papadopoulos and Dr. Costas N. Karatzas sooner or later. You possibly can study extra about Acesis BioMed and their work to rework males’s well being by visiting their web site right here. If you want to subscribe to my free weekly e-newsletter and skim articles about improvements in discipline, you may go to me at MenAlive.com and subscribe to the e-newsletter right here.