An fascinating examine from Miquel Serra-Burriel et al. (2024) examines the impression of genericization on drug costs throughout 8 high-income nations (Australia, Canada, France, Germany, Japan, Switzerland, UK, and US). The authors used 2011-2020 IQVIA MIDAS information throughout 505 novel originator medicine. They discovered that:
Value decreases had been statistically important over the 8 years after patent expiration, with the quickest worth declines noticed within the US: 32% (95% CI, 24%-39%) in yr 1 after patent expiration and 82% (95% CI, 71%-89%) within the 8 years after patent expiration. Estimates for different nations ranged from a lower of 64% in Australia to 18% in Switzerland within the 8 years after expiration. The associated fee-effectiveness simulation mannequin indicated that not accounting for generic entry into the market might produce biased incremental cost-effectiveness ratios of 40% to −40%, relying on the state of affairs.
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